논문
Dong Hwan Kim, Jaehyeon Kim, Hakmin Lee, Dongyun Lee, So Myoung Im, Ye Eun Kim, Miryeong Yoo, Yong-Pil Cheon, Jason C. Bartz, Young-Jin Son, Eun-Kyoung Choi, Yong-Sun Kim, Jae-Ho Jeon, Hyo Shin Kim, Sungeun Lee, Chongsuk Ryou & Tae-gyu Nam (2023) Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues. Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
Juhyeon Son, Hansol Cha, Sungeun Lee, Yongwoong Bae, Chongsuk Ryou & Sang Yeol Lee (2023) Ursonic acid inhibits migration and invasion of human osteosarcoma cells through the suppression of mitogen-activated protein kinases and matrix metalloproteinases. Molecular Biology Reports volume 50, pages4029–4038
HyunJung Park, Jaehyeon Kim,
Chongsuk
Ryou(2023) A three-dimensional spheroid co-culture system of neurons
and astrocytes derived from Alzheimer's disease patients for drug efficacy
testing. Cell Proliferation e13399
Sungeun Lee, Hakmin Lee, Jaehyeon Kim, Ji Hoon Kim, Eun Mei Gao, Yoonjeong Lee, Miryeong Yoo, Trang H. T. Trinh, Jieun Kim, Chul Young Kim and Chongsuk Ryou(2023) The Effect of Curcuma phaeocaulis Valeton (Zingiberaceae) Extract on Prion Propagation in Cell-Based and Animal Models. International Journal of Molecular Sciences 2023, 24, 182
Jae-Hyeon Lee, Seung Hyun
Park, Chongsuk
Ryou, Myung Chan Gye(2022) Phthalate plasticizer decreases the
prion-like protein doppel essential for structural integrity and function of
spermatozoa. Ecotoxicology and Environmental Safety volume 246, November 2022,
114159
Hakmin Lee, Jaehyeon Kim,Young Jin Lee, Sungeun
Lee, Chongsuk Ryou(2022) The Effect of Plassminogen-Derived Peptides PrPSc Formation. International Journal of
Peptide Rerearch and Therapeutics volume 28, Article number:56(2022)
Charles E Mays, Trang H. T.
Trinh, Glenn Telling, Hae-Eun Kang, Chongsuk Ryou(2022) Endoproteolysis of
cellular prion protein by plasmin hinders propagation of prions. Front
Molecular Neuroscience, 2022; 15:990136
JiaoJi Li, Chongsuk Ryou,
Dae-Hwan Kim(2020) Effects of SGI-1027 on Formation and Elimination of PrPSc in
Prion-Infected Cells. MOLECULAR CELL BIOLOGY 54(3):412-415
Sungeun Lee, Hee-Gyoo
Kang, Chongsuk Ryou, Yong-Pil Cheon (2020) Spatiotemporal expression of
aquaporin 9 is critical for the antral growth of mouse ovarian
follicles. Biology of Reproduction 103(4):828-839
Trang H.T.Trinh, Jeeyoung
Kim, Chul-Hoon Lee, Chongsuk Ryou (2019) Non-ionic detergents Nonidet P-40 and
Triton X-100 increase enzymatic activity of plasmin. Biochemical and
Biophysical Research Communications 512(2):314-318
Dae-Hwan Kim, Chunyan Ren,
Chongsuk Ryou, Jiaojie Li (2019) Direct interaction of DNMT inhibitors to PrPC
suppresses pathogenic process of prion. Acta Pharmaceutica Sinica B
9(5):952-959
Sungeun Lee, Trang H.T.
Trinh, Miryeong Yoo, Junwu Shin, Hakmin Lee, Jaehyeon Kim, Euimin Hwang, Yong-beom
Lim, Chongsuk Ryou (2019) Self-Assembling Peptides and Their Application in the
Treatment of Diseases. International Journal of Molecular Sciences
20(23):5850
Juhye Kim, Sunyeong Cha,
Min Young Lee, Yeon Jeong Hwang, Eunhyeok Yang, Chongsuk Ryou, Hyo-Il Jung and
Yong-Pil Cheon (2018) Chronic Low-Dose Nonylphenol or Di-(2-ethylhexyl)
Phthalate has a Different Estrogen-like Response in Mouse
Uterus. Development & Reproduction 22(4):379-391
YuJin Lee, Okkeun Jung,
Jongsung Lee, Juhyeon Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee (2018)
Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via
activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling
pathways. Nutrition Research 58:62-71
Hae-Eun Kang, Youngwon Mo,
Raihah Abd Rahim, Hye-Mi Lee and Chongsuk Ryou(2017) Prion Diagnosis:
Application of Real-Time Quaking-Induced Conversion BioMed Research
International 2017:8
Waqas M, Jeong W-j, Lee
Y-J, Kim DH, Ryou C, Lim Y-b (2017) pH-dependent in-cell self-assembly of
peptide inhibitors increases the anti-prion activity while decreasing the
cytotoxicity. Biomacromolecules 18(3):943-950
Waqas M, Lee HM, Kim J,
Telling G, Kim JK, Kim DH, Ryou C. (2017) Effect of poly-L-arginine in
inhibiting scrapie prion protein of cultured cells. Molecular and Cellular
Biochemistry 428(1-2):57–66
Omer Salman Qureshi,
Hyung-Seo Kim, Alam Zeb, Jin-Seok Choi, Hoo-Seong Kim, Jung-Eun Kwon, Myung-Sic
Kim, Jong-Ho Kang, Chongsuk Ryou, Jeong-sook Park & Jin-Ki
Kim(2017)Sustained release docetaxel-incorporated lipid nanoparticles with
improved pharmacokinetics for oral and parenteral administration. J
Microencapsul 34(3):250-261
Okkeun Jung, Jongsung Lee,
YuJin Lee, Jung-Mi Yun, Young-Jin Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee
(2016) Timosaponin AIII inhibits migration and invasion of A549 human
non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by
inhibitions of ERK1/2, Src/FAK and β-catenin signaling
pathways. Bioorg Med Chem Lett 26(16):3963-3967
Titlow WB, Waqas M, Lee J,
Cho JY, Lee SY, Kim DH, Ryou C (2016) Effect of polylysine to scrapie prion
protein propagation in spleen during asymptomatic stage of experimental prion
disease in mice. Journal of Microbiology and Biotechnology 26(9): 1657-1660
Jeon J, Kim J, Park S,
Ryou C, Kim C (2016) Preparative purification of plasmin activity stimulating
phenolic derivatives from Gastrodia elata using centrifugal partition
chromatography. Biomedical Chromatography 30(6):976-982.
Suh H, Choi K-w, Lee J,
Ryou C, Rhee H, Lee C-H (2016) Effects of a novel carbocyclic analog of
pyrrolo[2,3-d]pyrimidine nucleoside on pleiotropic induction of cell death in
prostate cancer cells with different androgen responsiveness. Bioorganic &
Medicinal Chemistry Letters 26(4):1130-1135
Choi K-w, Suh H, Oh HL,
Ryou C, Lee C-H (2016) p21Cip1 induces apoptosis via binding to Bcl-2 in
prostate cancer LNCaP cells treated with MCS-C3, a novel carbocyclic analog of
pyrrolopyrimidine. Anticancer Research 36(1):213-220
Kim JH, Cho EB, Lee J,
Jung O, Ryu BJ, Kim SH, Cho JY, Ryou C, Lee SY (2015) Emetine inhibits
migration and invasion of human non-small-cell lung cancer cells via regulation
of ERK and p38 signaling pathways. Chemico-Biological Interactions
242(2015):25-33
Hossen MJ, Kim SC, Son YJ,
Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim HG, Chung WJ, Yoon K, Ryou C,
Lee SY, Kim JH, Cho JY (2015) AP-1-Targeting Anti-Inflammatory Activity of the
Methanolic Extract of Persicaria chinensis. Evidence-Based Complementary and
Alternative Medicine 2015:1-11
Lee J, Moh S-H, Ryou C,
Kim D-H (2015) Enhanced formation of scrapie prion protein in cultured cells by
treatment with mycosporine-like amino acids (MAAs). Korean Journal of
Microbiology and Biotechnology 43(2):91-96
Lee J, Hyeon JW, Kim SY,
Hwang K-J, Ju YR, Ryou C (2015) Laboratory diagnosis and surveillance of
Creutzfeldt–Jakob disease. Journal of Medical
Virology 87(1):175-86
Kim D-H, Lee H-M, Ryou C
(2014) Evaluation of infective property of recombinant prion protein amyloids
in cultured cells overexpressing cellular prion protein. Journal of Korean
Medical Science 29(12):1604-1609
Lee H-M, Ryou C (2014)
Targeting of poly(L-lysine) to organs that propagate prions. Journal of
Bioactive and Compatible Polymers 29(5):432–444
Yi Y-S, Son Y-J, Ryou C,
Sung G-H, Kim J-H, Cho JY (2014) Functional roles of Syk in macrophage-mediated
inflammatory responses. Mediators of Inflammation 2014:270302, 1-12
Kim S-G, Lee H-M, Ryou C
(2014) Parameters that affect macromolecular self-assembly of prion protein.
Protein Journal 33:243-252
Titlow WB, Lee C-H, Ryou C
(2013) Characterization of toxicological properties of L-lysine polymers in
CD-1 mice. Journal of Microbiology and Biotechnology 23(7): 1015-1022
Jackson KS, Yeom J, Han Y,
Bae Y, Ryou C (2013) Preference toward a polylysine enantiomer in inhibiting
prions. Amino Acids 44:993-1000
Mays CE, Yeom J, Kang H-E,
Bian J, Khaychuk V, Kim Y, Bartz JC, Telling GC, Ryou C (2011) In vitro
amplification of misfolded prion protein using lysate of cultured cells. PLoS
ONE 6(3):e18047.
Ryou C, Titlow W, Mays CE,
Bae Y, Kim S (2011) The suppression of prion propagation using poly-L-lysine by
targeting plasminogen that stimulates prion protein conversion.
Biomaterials 32(11):3141–3149
Lee H-J, Maeng K, Dang
H-T, Kang G-J, Ryou C, Jung J, Kang H-K, Prchal J, Yoo E-S, Yoon D (2011)
Anti-inflammatory effect of methyl dehydro-jasmonate is mediated by the NF-κB
pathway. Journal of Molecular Medicine 89(1):83-90
Mays CE, Ryou C (2011)
Plasminogen: a cellular protein cofactor for PrPSc propagation.
Prion 5(1):22-27
Mays CE, Ryou C (2010)
Plasminogen stimulates propagation of protease-resistant prion protein in
vitro. FASEB Journal 24(12):5102-5112.
Lim Y-b, Mays CE, Kim Y,
Titlow W, Ryou C (2010) The inhibition of prions through blocking prion
conversion by permanently charged branched polyamines of low cytotoxicity.
Biomaterials 31(8):2025-2033
Kim Y, Han B, Titlow W,
Mays CE, Kwon M, Ryou C(2009) Utility of RNAi-mediated prnp gene silencing in
neuroblastoma cells permanently infected by prions: Potentials and limitations.
Antiviral Research 84(2):185-193
Mays CE, Titlow W, Seward
T, Telling GC, Ryou C (2009) Enhancement of protein misfolding cyclic
amplification by using concentrated cellular prion protein source. Biochemical
Biophysical Research Communications 388(2): 306–310.
Kim Y, Song J, Mays CE,
Titlow W, Yoon D, Ryou C (2009) Changes in gene expression of kringle
domain-containing proteins in murine brains and neuroblastoma cells infected by
prions. Molecular and Cellular Biochemistry 328(1-2):177-182
Ryou C, Mays CE (2008)
Prion propagation in vitro: are we there yet? International Journal of Medical
Sciences, 5(6):347-353.
Shin W, Lee B, Hong S,
Ryou C, Kwon, M (2008) Cloning and expression of a prion protein (PrP) gene
from Korean bovine (Bos taurus coreanae) and production of rabbit anti-bovine
PrP antibody. Biotechnology Letters, 30:1705-1711.
Mays CE, Kang H-E, Kim Y,
Shim SH, Bang J-E, Woo H-J, Cho Y-H, Kim J-B, Ryou C (2008) CRBL cells:
Establishment, characterization and susceptibility to prion infection. Brain
Research 1208:170-180.
Ryou C (2007) Prions and
prion diseases: Fundamentals and mechanistic details. Journal of Microbiology
and Biotechnology 17(7):1059-1070.
Yung L, Huang Y, Lessard
P, Legname G, Lin ET, Baldwin MA, Prusiner SB, Ryou C, Guglielmo BJ (2004)
Pharmacokinetics of quinacrine in the treatment of prion disease. BMC
Infectious Diseases 4(1):53.
Ryou C, Legname G, Peretz
D, Craig JC, Baldwin MA, Prusiner SB (2003) Differential inhibition of prion
propagation by enantiomers of quinacrine. Laboratory Investigation,
83(6):837-843.
Ryou C, Prusiner SB,
Legname G (2003) Cooperative binding of dominant negative prion proteins to
kringle domains. Journal of Molecular Biology, 329(2):323-333.
Bosque PJ, Ryou C, Telling
G, Peretz D, Legname G, DeArmond S, Prusiner SB (2002) Prions in skeletal
muscle. Proceedings of National Academy of Science, U. S. A., 99(6):3812-3817.
Hadden TJ, Ryou C, Zhu L,
Miller RE (2002) CAAT/Enhancer Binding Protein activates an enhancer in the
glutamine synthetase distal 5'-flanking sequence. Archives of Biochemistry and
Biophysics, 397(2): 258-261.
Lee J, Ryou C, Jeon BK,
Lee P, Woo H-J, Kwon M (2002) Gene cloning and nucleotide sequence of human dihydrolipoamide
dehydrogenase-binding protein. Asian-Australasian Journal of Animal Sciences,
15(3):421-426.
Ryou C, Chung T, Kwon M
(2001) Molecular cloning and hyperexpression of a Bt gene, cryIAc, in
Escherichia coli DH5a: production and usage of anti-cryIAc antibody. Journal of
Microbiology and Biotechnology, 11(6):1093-1098.
Lee J, Ryou C, Kwon M
(2001) Molecular cloning and expression of human dihydrolipoamide
dehydrogenase-binding protein in Escherichia coli. Journal of Microbiology and
Biotechnology, 11(4):592-597.
Kwon M, Lee JM, Jeon BK,
Oh SG, Ryou C, Oh BH (2001) RFLP analysis of a gene for blood coagulation
factor IX in Korean. Korean Journal of Obstetrics and Gynecology,
44(3):506-512.
Ryou C, Kim J-B, Kwon M
(2000) Immunochemical studies on expression of quinoproteins in Escherichia
coli. Journal of Microbiology and Biotechnology, 10(1):95-98.
Oh BH, Lee JM, Lee J, Lee
KH, Jung AY, Ryou C, Kwon M. (2000) A case of pregnant woman with
46,X,del(X)(q26) Turner karyotype whose fetus shows the same karyotype. Korean
Journal of Obstetrics and Gynecology, 43(4):721-724.
Lim JY, Shin CS, Chung
E-J, Kim JS, Kim HU, Oh SJ, Choi W-B, Ryou C, Kim JB, Kwon M, Chung TY, Song
SI, Kim J-K, Nahm BH, Hwang YS, Eun MY, Lee JS, Cheong J-J, Choi YD. (2000)
Analysis of expressed sequence tagsfrom Brassica rapa L. ssp. pekinensis.
Molecules and Cells, 10(4):399-404.
Cho KS, Jang JE, Ryou C,
Kwon M. (1999) Development of Transgenic Plant (Codonopsis lanceolata Trautv.)
harboring a bialaphos resistance gene, bar. Korean Journal of Plant Tissue
Culture, 26(4): 281-287.
Hadden TJ, Ryou C, Miller
RE. (1997) Elements in the distal 5’-flanking sequence and the
first intron function cooperatively to regulate glutamine synthetase gene
expression during adipocyte differentiation. Nucleic Acids Research,
25(19):3930-3936.
Yu HJ, Kim J, Ryou C, Kwon
M (1997) Generation of ETSs from dark-grown seedling cDNA of chinese cabbage.
Korean Journal of Genetics, 19(3):205-213.
Jang S, Ryou C, Kim J, Lee
P, Kwon M (1997) Construction of a mutant PU.1 cDNA clone, pJKS142A.
Sungkyunkwan University Journal of Natural Sciences and Technology
3(2):107-115.
Lee JM, Ryou C, Kwon M
(1997) Generation of transgenic plant (Nicotiana tabacum var. Petit Havana SR1)
harboring Bacillus thuringiensis insecticidal crystal protein gene, cry II A.
Korean Journal of Plant Tissue Culture, 24(5):305-311.
Ryou C, Yu S, Jang S, Kim
M, Kim J, Kwon M. (1995) Molecular cloning of mutant cDNA of PU.1 gene. Korean
Journal of Biotechnology and Bioengineering, 10(5): 499-509.
저서
Ryou C (2011) Prion
diseases, In: Encyclopedia of Life Sciences, John Wiley & Sons Inc.,
Chichester, UK Ryou C, Mays CE (2010) Prions (Chapter 8), In: Molecular aspects
of infectious diseases, Ed Saleh M, Nova Science Publisher, Hauppauge, New York.
Ryou C (2010)
Transmissible spongiform encephalopathy (Chapter 9), In: Molecular aspects of
infectious diseases, Ed. Saleh M, Nova Science Publisher, Hauppauge, New
York.
Kwon M, Ryou C (2004)
Genetic Engineering: Principles and Practices, Academy Book Publishing Co.,
Seoul, Korea
특허
류종석, 김철영, 이성은, 김지훈, 김재현(2022) 단백질응집에 의한 퇴행성 뇌질환 치료를 위한 아출
유래 약학 조성물, 출원번호 10-2022-0054006
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(2021.08.31)
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전용필 류종석(2020) 109번째 아미노산이 메티오닌인 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1021005100000 (2020.04.07)
전용필 류종석(2020) 109번째 아미노산이 아이소류신인 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1021005090000 (2020.04.07)
전용필 류종석(2020) 109번째 아미노산이 메티오닌이고 23번째에서 89번째 아미노산을 코딩하는 서열을 제거한 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1020702570000 (2020.01.20)
임용범 류종석(2019) 세포 내부 pH 감응성 융합 펩티드 및 이를 유효성분으로 포함하는 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환을 예방 또는 치료하기 위한 약학 조성물, 등록번호 1019563020000 (2019.03.04)
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Articles
JiaoJi Li, Chongsuk Ryou,
Dae-Hwan Kim(2020) Effects of SGI-1027 on Formation and Elimination of PrPSc in
Prion-Infected Cells. MOLECULAR CELL BIOLOGY 54(3):412-415
Sungeun Lee, Hee-Gyoo
Kang, Chongsuk Ryou, Yong-Pil Cheon (2020) Spatiotemporal expression of
aquaporin 9 is critical for the antral growth of mouse ovarian
follicles. Biology of Reproduction ioaa108
Trang H.T.Trinh, Jeeyoung
Kim, Chul-Hoon Lee, Chongsuk Ryou (2019) Non-ionic detergents Nonidet P-40 and
Triton X-100 increase enzymatic activity of plasmin. Biochemical and
Biophysical Research Communications 512(2):314-318
Dae-Hwan Kim, Chunyan Ren,
Chongsuk Ryou, Jiaojie Li (2019) Direct interaction of DNMT inhibitors to PrPC
suppresses pathogenic process of prion. Acta Pharmaceutica Sinica B 9(5):952-959
Sungeun Lee, Trang H.T.
Trinh, Miryeong Yoo, Junwu Shin, Hakmin Lee, Jaehyeon Kim, Euimin Hwang,
Yong-beom Lim, Chongsuk Ryou (2019) Self-Assembling Peptides and Their
Application in the Treatment of Diseases. International Journal of
Molecular Sciences 20(23):5850
Juhye Kim, Sunyeong Cha,
Min Young Lee, Yeon Jeong Hwang, Eunhyeok Yang, Chongsuk Ryou, Hyo-Il Jung and
Yong-Pil Cheon (2018) Chronic Low-Dose Nonylphenol or Di-(2-ethylhexyl)
Phthalate has a Different Estrogen-like Response in Mouse Uterus. Development
& Reproduction 22(4):379-391
YuJin Lee, Okkeun Jung,
Jongsung Lee, Juhyeon Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee (2018)
Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via
activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling
pathways. Nutrition Research 58:62-71
Hae-Eun Kang, Youngwon Mo,
Raihah Abd Rahim, Hye-Mi Lee and Chongsuk Ryou(2017) Prion Diagnosis:
Application of Real-Time Quaking-Induced Conversion BioMed Research
International 2017:8
Waqas M, Jeong W-j, Lee
Y-J, Kim DH, Ryou C, Lim Y-b (2017) pH-dependent in-cell self-assembly of
peptide inhibitors increases the anti-prion activity while decreasing the
cytotoxicity. Biomacromolecules 18(3):943-950
Waqas M, Lee HM, Kim J,
Telling G, Kim JK, Kim DH, Ryou C. (2017) Effect of poly-L-arginine in
inhibiting scrapie prion protein of cultured cells. Molecular and Cellular
Biochemistry 428(1-2):57–66
Omer Salman Qureshi,
Hyung-Seo Kim, Alam Zeb, Jin-Seok Choi, Hoo-Seong Kim, Jung-Eun Kwon, Myung-Sic
Kim, Jong-Ho Kang, Chongsuk Ryou, Jeong-sook Park & Jin-Ki
Kim(2017)Sustained release docetaxel-incorporated lipid nanoparticles with
improved pharmacokinetics for oral and parenteral administration. J
Microencapsul 34(3):250-261
Okkeun Jung, Jongsung Lee,
YuJin Lee, Jung-Mi Yun, Young-Jin Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee
(2016) Timosaponin AIII inhibits migration and invasion of A549 human
non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by
inhibitions of ERK1/2, Src/FAK and β-catenin signaling
pathways. Bioorg Med Chem Lett 26(16):3963-3967
Titlow WB, Waqas M, Lee J,
Cho JY, Lee SY, Kim DH, Ryou C (2016) Effect of polylysine to scrapie prion
protein propagation in spleen during asymptomatic stage of experimental prion
disease in mice. Journal of Microbiology and Biotechnology 26(9): 1657-1660
Jeon J, Kim J, Park S,
Ryou C, Kim C (2016) Preparative purification of plasmin activity stimulating
phenolic derivatives from Gastrodia elata using centrifugal partition chromatography.
Biomedical Chromatography 30(6):976-982.
Suh H, Choi K-w, Lee J,
Ryou C, Rhee H, Lee C-H (2016) Effects of a novel carbocyclic analog of
pyrrolo[2,3-d]pyrimidine nucleoside on pleiotropic induction of cell death in
prostate cancer cells with different androgen responsiveness. Bioorganic &
Medicinal Chemistry Letters 26(4):1130-1135
Choi K-w, Suh H, Oh HL,
Ryou C, Lee C-H (2016) p21Cip1 induces apoptosis via binding to Bcl-2 in
prostate cancer LNCaP cells treated with MCS-C3, a novel carbocyclic analog of
pyrrolopyrimidine. Anticancer Research 36(1):213-220
Kim JH, Cho EB, Lee J,
Jung O, Ryu BJ, Kim SH, Cho JY, Ryou C, Lee SY (2015) Emetine inhibits
migration and invasion of human non-small-cell lung cancer cells via regulation
of ERK and p38 signaling pathways. Chemico-Biological Interactions 242(2015):25-33
Hossen MJ, Kim SC, Son YJ,
Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim HG, Chung WJ, Yoon K, Ryou C,
Lee SY, Kim JH, Cho JY (2015) AP-1-Targeting Anti-Inflammatory Activity of the
Methanolic Extract of Persicaria chinensis. Evidence-Based Complementary and
Alternative Medicine 2015:1-11
Lee J, Moh S-H, Ryou C,
Kim D-H (2015) Enhanced formation of scrapie prion protein in cultured cells by
treatment with mycosporine-like amino acids (MAAs). Korean Journal of
Microbiology and Biotechnology 43(2):91-96
Lee J, Hyeon JW, Kim SY,
Hwang K-J, Ju YR, Ryou C (2015) Laboratory diagnosis and surveillance of
Creutzfeldt–Jakob disease. Journal of Medical
Virology 87(1):175-86
Kim D-H, Lee H-M, Ryou C
(2014) Evaluation of infective property of recombinant prion protein amyloids
in cultured cells overexpressing cellular prion protein. Journal of Korean
Medical Science 29(12):1604-1609
Lee H-M, Ryou C (2014)
Targeting of poly(L-lysine) to organs that propagate prions. Journal of
Bioactive and Compatible Polymers 29(5):432–444
Yi Y-S, Son Y-J, Ryou C,
Sung G-H, Kim J-H, Cho JY (2014) Functional roles of Syk in macrophage-mediated
inflammatory responses. Mediators of Inflammation 2014:270302, 1-12
Kim S-G, Lee H-M, Ryou C
(2014) Parameters that affect macromolecular self-assembly of prion protein.
Protein Journal 33:243-252
Titlow WB, Lee C-H, Ryou C
(2013) Characterization of toxicological properties of L-lysine polymers in
CD-1 mice. Journal of Microbiology and Biotechnology 23(7): 1015-1022
Jackson KS, Yeom J, Han Y,
Bae Y, Ryou C (2013) Preference toward a polylysine enantiomer in inhibiting
prions. Amino Acids 44:993-1000
Mays CE, Yeom J, Kang H-E,
Bian J, Khaychuk V, Kim Y, Bartz JC, Telling GC, Ryou C (2011) In vitro
amplification of misfolded prion protein using lysate of cultured cells. PLoS
ONE 6(3):e18047.
Ryou C, Titlow W, Mays CE,
Bae Y, Kim S (2011) The suppression of prion propagation using poly-L-lysine by
targeting plasminogen that stimulates prion protein conversion.
Biomaterials 32(11):3141–3149
Lee H-J, Maeng K, Dang
H-T, Kang G-J, Ryou C, Jung J, Kang H-K, Prchal J, Yoo E-S, Yoon D (2011)
Anti-inflammatory effect of methyl dehydro-jasmonate is mediated by the NF-κB
pathway. Journal of Molecular Medicine 89(1):83-90
Mays CE, Ryou C (2011)
Plasminogen: a cellular protein cofactor for PrPSc propagation.
Prion 5(1):22-27
Mays CE, Ryou C (2010)
Plasminogen stimulates propagation of protease-resistant prion protein in
vitro. FASEB Journal 24(12):5102-5112.
Lim Y-b, Mays CE, Kim Y,
Titlow W, Ryou C (2010) The inhibition of prions through blocking prion
conversion by permanently charged branched polyamines of low cytotoxicity.
Biomaterials 31(8):2025-2033
Kim Y, Han B, Titlow W,
Mays CE, Kwon M, Ryou C(2009) Utility of RNAi-mediated prnp gene silencing in
neuroblastoma cells permanently infected by prions: Potentials and limitations.
Antiviral Research 84(2):185-193
Mays CE, Titlow W, Seward
T, Telling GC, Ryou C (2009) Enhancement of protein misfolding cyclic
amplification by using concentrated cellular prion protein source. Biochemical
Biophysical Research Communications 388(2): 306–310.
Kim Y, Song J, Mays CE,
Titlow W, Yoon D, Ryou C (2009) Changes in gene expression of kringle
domain-containing proteins in murine brains and neuroblastoma cells infected by
prions. Molecular and Cellular Biochemistry 328(1-2):177-182
Ryou C, Mays CE (2008)
Prion propagation in vitro: are we there yet? International Journal of Medical
Sciences, 5(6):347-353.
Shin W, Lee B, Hong S,
Ryou C, Kwon, M (2008) Cloning and expression of a prion protein (PrP) gene
from Korean bovine (Bos taurus coreanae) and production of rabbit anti-bovine
PrP antibody. Biotechnology Letters, 30:1705-1711.
Mays CE, Kang H-E, Kim Y,
Shim SH, Bang J-E, Woo H-J, Cho Y-H, Kim J-B, Ryou C (2008) CRBL cells:
Establishment, characterization and susceptibility to prion infection. Brain
Research 1208:170-180.
Ryou C (2007) Prions and
prion diseases: Fundamentals and mechanistic details. Journal of Microbiology
and Biotechnology 17(7):1059-1070.
Yung L, Huang Y, Lessard
P, Legname G, Lin ET, Baldwin MA, Prusiner SB, Ryou C, Guglielmo BJ (2004)
Pharmacokinetics of quinacrine in the treatment of prion disease. BMC
Infectious Diseases 4(1):53.
Ryou C, Legname G, Peretz
D, Craig JC, Baldwin MA, Prusiner SB (2003) Differential inhibition of prion
propagation by enantiomers of quinacrine. Laboratory Investigation,
83(6):837-843.
Ryou C, Prusiner SB,
Legname G (2003) Cooperative binding of dominant negative prion proteins to
kringle domains. Journal of Molecular Biology, 329(2):323-333.
Bosque PJ, Ryou C, Telling
G, Peretz D, Legname G, DeArmond S, Prusiner SB (2002) Prions in skeletal
muscle. Proceedings of National Academy of Science, U. S. A., 99(6):3812-3817.
Hadden TJ, Ryou C, Zhu L,
Miller RE (2002) CAAT/Enhancer Binding Protein activates an enhancer in the
glutamine synthetase distal 5'-flanking sequence. Archives of Biochemistry and
Biophysics, 397(2): 258-261.
Lee J, Ryou C, Jeon BK,
Lee P, Woo H-J, Kwon M (2002) Gene cloning and nucleotide sequence of human
dihydrolipoamide dehydrogenase-binding protein. Asian-Australasian Journal of
Animal Sciences, 15(3):421-426.
Ryou C, Chung T, Kwon M
(2001) Molecular cloning and hyperexpression of a Bt gene, cryIAc, in
Escherichia coli DH5a: production and usage of anti-cryIAc antibody. Journal of
Microbiology and Biotechnology, 11(6):1093-1098.
Lee J, Ryou C, Kwon M
(2001) Molecular cloning and expression of human dihydrolipoamide
dehydrogenase-binding protein in Escherichia coli. Journal of Microbiology and
Biotechnology, 11(4):592-597.
Kwon M, Lee JM, Jeon BK,
Oh SG, Ryou C, Oh BH (2001) RFLP analysis of a gene for blood coagulation
factor IX in Korean. Korean Journal of Obstetrics and Gynecology,
44(3):506-512.
Ryou C, Kim J-B, Kwon M
(2000) Immunochemical studies on expression of quinoproteins in Escherichia
coli. Journal of Microbiology and Biotechnology, 10(1):95-98.
Oh BH, Lee JM, Lee J, Lee
KH, Jung AY, Ryou C, Kwon M. (2000) A case of pregnant woman with 46,X,del(X)(q26)
Turner karyotype whose fetus shows the same karyotype. Korean Journal of
Obstetrics and Gynecology, 43(4):721-724.
Lim JY, Shin CS, Chung
E-J, Kim JS, Kim HU, Oh SJ, Choi W-B, Ryou C, Kim JB, Kwon M, Chung TY, Song
SI, Kim J-K, Nahm BH, Hwang YS, Eun MY, Lee JS, Cheong J-J, Choi YD. (2000)
Analysis of expressed sequence tagsfrom Brassica rapa L. ssp. pekinensis.
Molecules and Cells, 10(4):399-404.
Cho KS, Jang JE, Ryou C,
Kwon M. (1999) Development of Transgenic Plant (Codonopsis lanceolata Trautv.)
harboring a bialaphos resistance gene, bar. Korean Journal of Plant Tissue
Culture, 26(4): 281-287.
Hadden TJ, Ryou C, Miller
RE. (1997) Elements in the distal 5’-flanking sequence and the
first intron function cooperatively to regulate glutamine synthetase gene
expression during adipocyte differentiation. Nucleic Acids Research,
25(19):3930-3936.
Yu HJ, Kim J, Ryou C, Kwon
M (1997) Generation of ETSs from dark-grown seedling cDNA of chinese cabbage.
Korean Journal of Genetics, 19(3):205-213.
Jang S, Ryou C, Kim J, Lee
P, Kwon M (1997) Construction of a mutant PU.1 cDNA clone, pJKS142A.
Sungkyunkwan University Journal of Natural Sciences and Technology
3(2):107-115.
Lee JM, Ryou C, Kwon M
(1997) Generation of transgenic plant (Nicotiana tabacum var. Petit Havana SR1)
harboring Bacillus thuringiensis insecticidal crystal protein gene, cry II A.
Korean Journal of Plant Tissue Culture, 24(5):305-311.
Ryou C, Yu S, Jang S, Kim
M, Kim J, Kwon M. (1995) Molecular cloning of mutant cDNA of PU.1 gene. Korean
Journal of Biotechnology and Bioengineering, 10(5): 499-509.
Book and Book Chapters
Ryou C (2011) Prion
diseases, In: Encyclopedia of Life Sciences, John Wiley & Sons Inc.,
Chichester, UK Ryou C, Mays CE (2010) Prions (Chapter 8), In: Molecular aspects
of infectious diseases, Ed Saleh M, Nova Science Publisher, Hauppauge, New
York.
Ryou C (2010)
Transmissible spongiform encephalopathy (Chapter 9), In: Molecular aspects of
infectious diseases, Ed. Saleh M, Nova Science Publisher, Hauppauge, New
York.
Kwon M, Ryou C (2004)
Genetic Engineering: Principles and Practices, Academy Book Publishing Co.,
Seoul, Korea
Patents
Ryou C, Trang H.T.Trinh(2021) The Composition Comprised of Aspirin for Preventing or Treating Prion Diseases, Korean Patent Registration #1022108930000
Ryou C(2021) Method for detecting prions using silicon nanoribbon field effect transistor,Korean Patent Registration, #1021249810000
Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS METHIONINE AND APPLICATIONS THEREOF, Korean Patent Registration #1021005100000
Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS ISOLEUCINE AND APPLICATIONS THEREOF, Korean Patent Registration #1021005090000
Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS METHIONINE AND FROM 23TH TO 89TH AMINO ACID CODING SEQUENCES ARE ELIMINATED, AND APPLICATIONS THEREOF, Korean Patent Registration #1020702570000
Yong-beom Lim, Ryou C(2019) intracellular pH-responsive fusion peptide, phamaceutical composition for treatment of protein aggregation and misfolding related diseases, Korean Patent Registration #1019563020000