논문
Miryeong Yoo,
Sungeun Lee, Jieun Kim, Sunyeong Cha, Min Young Lee,
Yeon Jeong Hwang, Woo-Ri Ko, Taeeun Kim, A-ran Kim,
Trang H. T. Trinh, Young-Mi Kim, Yong-Pil Cheon,
Chongsuk Ryou (2025) Partial Deletion of the Carboxyl- Terminal
Signal Sequence of the Cellular Prion Protein Alters Protein Expression via
Endoplasmic Reticulum–Associated Degradation. The FASEB Journal, 39(17):e71016
Sungeun Lee, Jieun Kim, Yoonjeong Lee, Miryeong Yoo, Jaehyeon Kim, Hyun
Joo Sohn, Chongsuk Ryou (2025) Delayed progression of prion
disease in mice by polyarginine-facilitated prevention of PrPSc propagation in
the spleen. Neurotherapeutics, 22(3):e00560
Dong Hwan Kim,
Jaehyeon Kim, Hakmin Lee, Dongyun Lee, So Myoung Im, Ye Eun Kim, Miryeong Yoo,
Yong-Pil Cheon, Jason C. Bartz, Young-Jin Son, Eun-Kyoung Choi, Yong-Sun Kim,
Jae-Ho Jeon, Hyo Shin Kim, Sungeun Lee, Chongsuk Ryou & Tae-gyu
Nam (2023) Synthesis and anti-prion aggregation activity of
acylthiosemicarbazide analogues. Journal of Enzyme
Inhibition and Medicinal Chemistry, 38(1):2191164
Juhyeon Son, Hansol
Cha, Sungeun Lee, Yongwoong Bae, Chongsuk Ryou & Sang Yeol
Lee (2023) Ursonic acid inhibits migration and invasion of human
osteosarcoma cells through the suppression of mitogen-activated protein kinases
and matrix metalloproteinases. Molecular Biology Reports, 50(5):4029–4038
HyunJung
Park, Jaehyeon Kim, Chongsuk Ryou (2023) A three-dimensional
spheroid co-culture system of neurons and astrocytes derived from Alzheimer's
disease patients for drug efficacy testing. Cell Proliferation, 56(6):e13399
Sungeun Lee, Hakmin
Lee, Jaehyeon Kim, Ji Hoon Kim, Eun Mei Gao, Yoonjeong Lee, Miryeong Yoo, Trang
H. T. Trinh, Jieun Kim, Chul Young Kim and Chongsuk Ryou (2022) The Effect
of Curcuma phaeocaulis Valeton (Zingiberaceae) Extract on Prion Propagation in
Cell-Based and Animal Models. International Journal of Molecular Sciences,
24(1):182
Jae-Hyeon Lee, Seung
Hyun Park, Chongsuk Ryou, Myung Chan Gye (2022) Phthalate plasticizer
decreases the prion-like protein doppel essential for structural integrity and
function of spermatozoa. Ecotoxicology and Environmental Safety, 246:114159
Hakmin Lee, Jaehyeon
Kim, Young Jin Lee, Sungeun Lee, Chongsuk Ryou (2022) The Effect of
Plassminogen-Derived Peptides PrPSc Formation. International Journal of Peptide Rerearch
and Therapeutics, 28(2):56
Charles E Mays, Trang
H. T. Trinh, Glenn Telling, Hae-Eun Kang, Chongsuk Ryou (2022) Endoproteolysis
of cellular prion protein by plasmin hinders propagation of prions. Front
Molecular Neuroscience, 2022(15):1-14
JiaoJi Li, Chongsuk Ryou, Dae-Hwan Kim (2020) Effects of SGI-1027 on
Formation and Elimination of PrPSc in Prion-Infected Cells. MOLECULAR CELL
BIOLOGY, 54(3):412-415
Sungeun Lee, Hee-Gyoo Kang, Chongsuk Ryou, Yong-Pil Cheon (2020)
Spatiotemporal expression of aquaporin 9 is critical for the antral growth of
mouse ovarian follicles. Biology of Reproduction, 103(4):828-839
Trang H.T.Trinh, Jeeyoung Kim, Chul-Hoon Lee, Chongsuk Ryou (2019)
Non-ionic detergents Nonidet P-40 and Triton X-100 increase enzymatic activity
of plasmin. Biochemical and Biophysical Research Communications,
512(2):314-318
Dae-Hwan Kim, Chunyan Ren, Chongsuk Ryou, Jiaojie Li (2019) Direct
interaction of DNMT inhibitors to PrPC suppresses pathogenic process of
prion. Acta Pharmaceutica Sinica B, 9(5):952-959
Sungeun Lee, Trang H.T. Trinh, Miryeong Yoo, Junwu Shin, Hakmin Lee,
Jaehyeon Kim, Euimin Hwang, Yong-beom Lim, Chongsuk Ryou (2019) Self-Assembling
Peptides and Their Application in the Treatment of Diseases. International
Journal of Molecular Sciences, 20(23):5850
Juhye Kim, Sunyeong Cha, Min Young Lee, Yeon Jeong Hwang, Eunhyeok Yang,
Chongsuk Ryou, Hyo-Il Jung and Yong-Pil Cheon (2018) Chronic Low-Dose
Nonylphenol or Di-(2-ethylhexyl) Phthalate has a Different Estrogen-like
Response in Mouse Uterus. Development & Reproduction, 22(4):379-391
YuJin Lee, Okkeun Jung, Jongsung Lee, Juhyeon Son, JaeYoul Cho, Chongsuk
Ryou, SangYeol Lee (2018) Maclurin exerts anti-cancer effects on PC3 human
prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT,
and c-Myc signaling pathways. Nutrition Research, 58:62-71
Hae-Eun Kang, Youngwon Mo, Raihah Abd Rahim, Hye-Mi Lee and Chongsuk Ryou
(2017) Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion. BioMed
Research International, 2017:8
Waqas M, Jeong W-j, Lee Y-J, Kim DH, Ryou C, Lim Y-b (2017) pH-dependent
in-cell self-assembly of peptide inhibitors increases the anti-prion activity
while decreasing the cytotoxicity. Biomacromolecules, 18(3):943-950
Waqas M, Lee HM, Kim J, Telling G, Kim JK, Kim DH, Ryou C. (2017) Effect
of poly-L-arginine in inhibiting scrapie prion protein of cultured cells.
Molecular and Cellular Biochemistry, 428(1-2):57–66
Omer Salman Qureshi, Hyung-Seo Kim, Alam Zeb, Jin-Seok Choi, Hoo-Seong
Kim, Jung-Eun Kwon, Myung-Sic Kim, Jong-Ho Kang, Chongsuk Ryou, Jeong-sook Park
& Jin-Ki Kim (2017) Sustained release docetaxel-incorporated lipid
nanoparticles with improved pharmacokinetics for oral and parenteral
administration. J Microencapsul, 34(3):250-261
Okkeun Jung, Jongsung Lee, YuJin Lee, Jung-Mi Yun, Young-Jin Son, JaeYoul
Cho, Chongsuk Ryou, SangYeol Lee (2016) Timosaponin AIII inhibits migration and
invasion of A549 human non-small-cell lung cancer cells via attenuations of
MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and β-catenin signaling
pathways. Bioorg Med Chem Lett, 26(16):3963-3967
Titlow WB, Waqas M, Lee J, Cho JY, Lee SY, Kim DH, Ryou C (2016) Effect
of polylysine to scrapie prion protein propagation in spleen during
asymptomatic stage of experimental prion disease in mice. Journal of
Microbiology and Biotechnology, 26(9): 1657-1660
Jeon J, Kim J, Park S, Ryou C, Kim C (2016) Preparative purification of
plasmin activity stimulating phenolic derivatives from Gastrodia elata using
centrifugal partition chromatography. Biomedical Chromatography, 30(6):976-982.
Suh H, Choi K-w, Lee J, Ryou C, Rhee H, Lee C-H (2016) Effects of a novel
carbocyclic analog of pyrrolo[2,3-d]pyrimidine nucleoside on pleiotropic
induction of cell death in prostate cancer cells with different androgen
responsiveness. Bioorganic & Medicinal Chemistry Letters, 26(4):1130-1135
Choi K-w, Suh H, Oh HL, Ryou C, Lee C-H (2016) p21Cip1 induces apoptosis
via binding to Bcl-2 in prostate cancer LNCaP cells treated with MCS-C3, a
novel carbocyclic analog of pyrrolopyrimidine. Anticancer Research,
36(1):213-220
Kim JH, Cho EB, Lee J, Jung O, Ryu BJ, Kim SH, Cho JY, Ryou C, Lee SY
(2015) Emetine inhibits migration and invasion of human non-small-cell lung
cancer cells via regulation of ERK and p38 signaling pathways.
Chemico-Biological Interactions, 242(2015):25-33
Hossen MJ, Kim SC, Son YJ, Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim
HG, Chung WJ, Yoon K, Ryou C, Lee SY, Kim JH, Cho JY (2015) AP-1-Targeting
Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis.
Evidence-Based Complementary and Alternative Medicine, 2015:1-11
Lee J, Moh S-H, Ryou C, Kim D-H (2015) Enhanced formation of scrapie
prion protein in cultured cells by treatment with mycosporine-like amino acids
(MAAs). Korean Journal of Microbiology and Biotechnology, 43(2):91-96
Lee J, Hyeon JW, Kim SY, Hwang K-J, Ju YR, Ryou C (2015) Laboratory
diagnosis and surveillance of Creutzfeldt–Jakob disease. Journal of Medical
Virology, 87(1):175-86
Kim D-H, Lee H-M, Ryou C (2014) Evaluation of infective property of
recombinant prion protein amyloids in cultured cells overexpressing cellular
prion protein. Journal of Korean Medical Science, 29(12):1604-1609
Lee H-M, Ryou C (2014) Targeting of poly(L-lysine) to organs that
propagate prions. Journal of Bioactive and Compatible Polymers, 29(5):432–444
Yi Y-S, Son Y-J, Ryou C, Sung G-H, Kim J-H, Cho JY (2014) Functional
roles of Syk in macrophage-mediated inflammatory responses. Mediators of
Inflammation, 2014(270302):1-12
Kim S-G, Lee H-M, Ryou C (2014) Parameters that affect macromolecular
self-assembly of prion protein. Protein Journal, 33:243-252
Titlow WB, Lee C-H, Ryou C (2013) Characterization of toxicological
properties of L-lysine polymers in CD-1 mice. Journal of Microbiology and
Biotechnology, 23(7): 1015-1022
Jackson KS, Yeom J, Han Y, Bae Y, Ryou C (2013) Preference toward a
polylysine enantiomer in inhibiting prions. Amino Acids, 44:993-1000
Mays CE, Yeom J, Kang H-E, Bian J, Khaychuk V, Kim Y, Bartz JC, Telling
GC, Ryou C (2011) In vitro amplification of misfolded prion protein using
lysate of cultured cells. PLoS ONE 6(3):e18047.
Ryou C, Titlow W, Mays CE, Bae Y, Kim S (2011) The suppression of prion
propagation using poly-L-lysine by targeting plasminogen that stimulates prion
protein conversion. Biomaterials, 32(11):3141–3149
Lee H-J, Maeng K, Dang H-T, Kang G-J, Ryou C, Jung J, Kang H-K, Prchal J,
Yoo E-S, Yoon D (2011) Anti-inflammatory effect of methyl dehydro-jasmonate is
mediated by the NF-κB pathway. Journal of Molecular Medicine, 89(1):83-90
Mays CE, Ryou C (2011) Plasminogen: a cellular protein cofactor for PrPSc
propagation. Prion, 5(1):22-27
Mays CE, Ryou C (2010) Plasminogen stimulates propagation of
protease-resistant prion protein in vitro. FASEB Journal, 24(12):5102-5112.
Lim Y-b, Mays CE, Kim Y, Titlow W, Ryou C (2010) The inhibition of prions
through blocking prion conversion by permanently charged branched polyamines of
low cytotoxicity. Biomaterials, 31(8):2025-2033
Kim Y, Han B, Titlow W, Mays CE, Kwon M, Ryou C (2009) Utility of
RNAi-mediated prnp gene silencing in neuroblastoma cells permanently infected
by prions: Potentials and limitations. Antiviral Research, 84(2):185-193
Mays CE, Titlow W, Seward T, Telling GC, Ryou C (2009) Enhancement of
protein misfolding cyclic amplification by using concentrated cellular prion
protein source. Biochemical Biophysical Research Communications, 388(2):
306–310.
Kim Y, Song J, Mays CE, Titlow W, Yoon D, Ryou C (2009) Changes in gene
expression of kringle domain-containing proteins in murine brains and
neuroblastoma cells infected by prions. Molecular and Cellular Biochemistry, 328(1-2):177-182
Ryou C, Mays CE (2008) Prion propagation in vitro: are we there yet?
International Journal of Medical Sciences, 5(6):347-353.
Shin W, Lee B, Hong S, Ryou C, Kwon, M (2008) Cloning and expression of a
prion protein (PrP) gene from Korean bovine (Bos taurus coreanae) and
production of rabbit anti-bovine PrP antibody. Biotechnology Letters,
30:1705-1711.
Mays CE, Kang H-E, Kim Y, Shim SH, Bang J-E, Woo H-J, Cho Y-H, Kim J-B,
Ryou C (2008) CRBL cells: Establishment, characterization and susceptibility to
prion infection. Brain Research, 1208:170-180.
Ryou C (2007) Prions and prion diseases: Fundamentals and mechanistic
details. Journal of Microbiology and Biotechnology, 17(7):1059-1070.
Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin MA, Prusiner SB,
Ryou C, Guglielmo BJ (2004) Pharmacokinetics of quinacrine in the treatment of
prion disease. BMC Infectious Diseases, 4(1):53.
Ryou C, Legname G, Peretz D, Craig JC, Baldwin MA, Prusiner SB (2003)
Differential inhibition of prion propagation by enantiomers of quinacrine.
Laboratory Investigation, 83(6):837-843.
Ryou C, Prusiner SB, Legname G (2003) Cooperative binding of dominant
negative prion proteins to kringle domains. Journal of Molecular Biology,
329(2):323-333.
Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond S, Prusiner
SB (2002) Prions in skeletal muscle. Proceedings of National Academy of
Science, U. S. A., 99(6):3812-3817.
Hadden TJ, Ryou C, Zhu L, Miller RE (2002) CAAT/Enhancer Binding Protein
activates an enhancer in the glutamine synthetase distal 5'-flanking sequence.
Archives of Biochemistry and Biophysics, 397(2):258-261.
Lee J, Ryou C, Jeon BK, Lee P, Woo H-J, Kwon M (2002) Gene cloning and
nucleotide sequence of human dihydrolipoamide dehydrogenase-binding protein.
Asian-Australasian Journal of Animal Sciences, 15(3):421-426.
Ryou C, Chung T, Kwon M (2001) Molecular cloning and hyperexpression of a
Bt gene, cryIAc, in Escherichia coli DH5a: production and usage of anti-cryIAc
antibody. Journal of Microbiology and Biotechnology, 11(6):1093-1098.
Lee J, Ryou C, Kwon M (2001) Molecular cloning and expression of human
dihydrolipoamide dehydrogenase-binding protein in Escherichia coli. Journal of
Microbiology and Biotechnology, 11(4):592-597.
Kwon M, Lee JM, Jeon BK, Oh SG, Ryou C, Oh BH (2001) RFLP analysis of a
gene for blood coagulation factor IX in Korean. Korean Journal of Obstetrics
and Gynecology, 44(3):506-512.
Ryou C, Kim J-B, Kwon M (2000) Immunochemical studies on expression of
quinoproteins in Escherichia coli. Journal of Microbiology and Biotechnology,
10(1):95-98.
Oh BH, Lee JM, Lee J, Lee KH, Jung AY, Ryou C, Kwon M. (2000) A case of
pregnant woman with 46,X,del(X)(q26) Turner karyotype whose fetus shows the
same karyotype. Korean Journal of Obstetrics and Gynecology, 43(4):721-724.
Lim JY, Shin CS, Chung E-J, Kim JS, Kim HU, Oh SJ, Choi W-B, Ryou C, Kim
JB, Kwon M, Chung TY, Song SI, Kim J-K, Nahm BH, Hwang YS, Eun MY, Lee JS,
Cheong J-J, Choi YD. (2000) Analysis of expressed sequence tags from Brassica
rapa L. ssp. pekinensis. Molecules and Cells, 10(4):399-404.
Cho KS, Jang JE, Ryou C, Kwon M. (1999) Development of Transgenic Plant
(Codonopsis lanceolata Trautv.) harboring a bialaphos resistance gene, bar.
Korean Journal of Plant Tissue Culture, 26(4):281-287.
Hadden TJ, Ryou C, Miller RE. (1997) Elements in the distal 5’-flanking
sequence and the first intron function cooperatively to regulate glutamine
synthetase gene expression during adipocyte differentiation. Nucleic Acids
Research, 25(19):3930-3936.
Yu HJ, Kim J, Ryou C, Kwon M (1997) Generation of ETSs from dark-grown
seedling cDNA of chinese cabbage. Korean Journal of Genetics, 19(3):205-213.
Jang S, Ryou C, Kim J, Lee P, Kwon M (1997) Construction of a mutant PU.1
cDNA clone, pJKS142A. Sungkyunkwan University Journal of Natural Sciences and
Technology 3(2):107-115.
Lee JM, Ryou C, Kwon M (1997) Generation of transgenic plant (Nicotiana tabacum var. Petit Havana SR1) harboring Bacillus thuringiensis insecticidal crystal protein gene, cry II A. Korean Journal of Plant Tissue Culture, 24(5):305-311.
Ryou C, Yu S, Jang S, Kim M, Kim J, Kwon M. (1995) Molecular cloning of mutant cDNA of PU.1 gene. Korean Journal of Biotechnology and Bioengineering, 10(5):499-509.
저서
Ryou C (2011) Prion
diseases, In: Encyclopedia of Life Sciences, John Wiley & Sons Inc.,
Chichester, UK Ryou C, Mays CE (2010) Prions (Chapter 8), In: Molecular aspects
of infectious diseases, Ed Saleh M, Nova Science Publisher, Hauppauge, New York.
Ryou C (2010)
Transmissible spongiform encephalopathy (Chapter 9), In: Molecular aspects of
infectious diseases, Ed. Saleh M, Nova Science Publisher, Hauppauge, New
York.
Kwon M, Ryou C (2004)
Genetic Engineering: Principles and Practices, Academy Book Publishing Co.,
Seoul, Korea
특허
류종석, 김철영, 이성은, 김지훈, 김재현(2022) 단백질응집에 의한 퇴행성 뇌질환 치료를 위한 아출
유래 약학 조성물, 출원번호 10-2022-0054006
(2022.05.02)
류종석, 김철영, 이성은(2022) 단백질응집 기반 프리온 질환치료를 위한 아출 유래 퓨라노다이에논을 포함하는 약학 조성물, 등록번호 10-2022-0051572 (2022.04.26)
남태규, 이동윤, 김동환, 김예은, 류종석, 김재현, 유미령, 이학민, 이성은(2021) 세미카바자이드 유도체화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 프리온 질환의 예방 또는 치료용 약학적 조성물, 등록번호 10-2021-0151609 (2021.11.05)
류종석 손영진(2021) 고순도 재조합 프리온 단백질의
대량 생산 방법, 등록번호 10-2298635-0000
(2021.08.31)
류종석 트린티후엔트랑(2021) 아스피린을 유효성분으로 포함하는 프리온 질환의 예방 또는 치료용 조성물, 등록번호 1022108930000 (2021.01.27)
류종석 아툴 쿨카르니(2020) 실리콘 나노리본 전계효과트랜지스터를 이용한 프리온 검출 방법, 등록번호 1021249810000 (2020.06.15)
전용필 류종석(2020) 109번째 아미노산이 메티오닌인 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1021005100000 (2020.04.07)
전용필 류종석(2020) 109번째 아미노산이 아이소류신인 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1021005090000 (2020.04.07)
전용필 류종석(2020) 109번째 아미노산이 메티오닌이고 23번째에서 89번째 아미노산을 코딩하는 서열을 제거한 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1020702570000 (2020.01.20)
임용범 류종석(2019) 세포 내부 pH 감응성 융합 펩티드 및 이를 유효성분으로 포함하는 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환을 예방 또는 치료하기 위한 약학 조성물, 등록번호 1019563020000 (2019.03.04)
류종석(2009) 프리온 질병 치료제, 등록번호 100881636 (2009.01.28)
류종석(2008) 변형 프리온 단백질에 의한 퇴행성 뇌질환의 치료제, 등록번호 100849422 (2008.07.24)
Patents
Ryou C, Trang H.T.Trinh(2021) The Composition Comprised of Aspirin for Preventing or Treating Prion Diseases, Korean Patent Registration #1022108930000
Ryou C(2021) Method for detecting prions using silicon nanoribbon field effect transistor,Korean Patent Registration, #1021249810000
Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS METHIONINE AND APPLICATIONS THEREOF, Korean Patent Registration #1021005100000
Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS ISOLEUCINE AND APPLICATIONS THEREOF, Korean Patent Registration #1021005090000
Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS METHIONINE AND FROM 23TH TO 89TH AMINO ACID CODING SEQUENCES ARE ELIMINATED, AND APPLICATIONS THEREOF, Korean Patent Registration #1020702570000
Yong-beom Lim, Ryou C(2019) intracellular pH-responsive fusion peptide, phamaceutical composition for treatment of protein aggregation and misfolding related diseases, Korean Patent Registration #1019563020000