publications

논문

Dong Hwan Kim, Jaehyeon Kim, Hakmin Lee, Dongyun Lee, So Myoung Im, Ye Eun Kim, Miryeong Yoo, Yong-Pil Cheon, Jason C. Bartz, Young-Jin Son, Eun-Kyoung Choi, Yong-Sun Kim, Jae-Ho Jeon, Hyo Shin Kim, Sungeun Lee, Chongsuk Ryou & Tae-gyu Nam (2023) Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues. Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1

Juhyeon Son, Hansol Cha, Sungeun Lee, Yongwoong Bae, Chongsuk Ryou & Sang Yeol Lee (2023) Ursonic acid inhibits migration and invasion of human osteosarcoma cells through the suppression of mitogen-activated protein kinases and matrix metalloproteinases. Molecular Biology Reports volume 50, pages4029–4038

HyunJung Park, Jaehyeon Kim, Chongsuk Ryou(2023) A three-dimensional spheroid co-culture system of neurons and astrocytes derived from Alzheimer's disease patients for drug efficacy testing. Cell Proliferation e13399

Sungeun Lee, Hakmin Lee, Jaehyeon Kim, Ji Hoon Kim, Eun Mei Gao, Yoonjeong Lee, Miryeong Yoo, Trang H. T. Trinh, Jieun Kim, Chul Young Kim and Chongsuk Ryou(2023) The Effect of Curcuma phaeocaulis Valeton (Zingiberaceae) Extract on Prion Propagation in Cell-Based and Animal Models. International Journal of Molecular Sciences 2023, 24, 182

Jae-Hyeon Lee, Seung Hyun Park, Chongsuk Ryou, Myung Chan Gye(2022) Phthalate plasticizer decreases the prion-like protein doppel essential for structural integrity and function of spermatozoa. Ecotoxicology and Environmental Safety volume 246, November 2022, 114159

Hakmin Lee, Jaehyeon Kim,Young Jin Lee, Sungeun Lee, Chongsuk Ryou(2022) The Effect of Plassminogen-Derived Peptides PrPSc Formation. International Journal of Peptide Rerearch and Therapeutics volume 28, Article number:56(2022)

Charles E Mays, Trang H. T. Trinh, Glenn Telling, Hae-Eun Kang, Chongsuk Ryou(2022) Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions. Front Molecular Neuroscience, 2022; 15:990136 

JiaoJi Li, Chongsuk Ryou, Dae-Hwan Kim(2020) Effects of SGI-1027 on Formation and Elimination of PrPSc in Prion-Infected Cells. MOLECULAR CELL BIOLOGY 54(3):412-415

Sungeun Lee, Hee-Gyoo Kang, Chongsuk Ryou, Yong-Pil Cheon (2020) Spatiotemporal expression of aquaporin 9 is critical for the antral growth of mouse ovarian follicles. Biology of Reproduction 103(4):828-839

Trang H.T.Trinh, Jeeyoung Kim, Chul-Hoon Lee, Chongsuk Ryou (2019) Non-ionic detergents Nonidet P-40 and Triton X-100 increase enzymatic activity of plasmin. Biochemical and Biophysical Research Communications 512(2):314-318

Dae-Hwan Kim, Chunyan Ren, Chongsuk Ryou, Jiaojie Li (2019) Direct interaction of DNMT inhibitors to PrPC suppresses pathogenic process of prion. Acta Pharmaceutica Sinica B 9(5):952-959

Sungeun Lee, Trang H.T. Trinh, Miryeong Yoo, Junwu Shin, Hakmin Lee, Jaehyeon Kim, Euimin Hwang, Yong-beom Lim, Chongsuk Ryou (2019) Self-Assembling Peptides and Their Application in the Treatment of Diseases. International Journal of Molecular Sciences 20(23):5850

Juhye Kim, Sunyeong Cha, Min Young Lee, Yeon Jeong Hwang, Eunhyeok Yang, Chongsuk Ryou, Hyo-Il Jung and Yong-Pil Cheon (2018) Chronic Low-Dose Nonylphenol or Di-(2-ethylhexyl) Phthalate has a Different Estrogen-like Response in Mouse Uterus. Development & Reproduction 22(4):379-391

YuJin Lee, Okkeun Jung, Jongsung Lee, Juhyeon Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee (2018) Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling pathways. Nutrition Research 58:62-71

Hae-Eun Kang, Youngwon Mo, Raihah Abd Rahim, Hye-Mi Lee and Chongsuk Ryou(2017) Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion BioMed Research International 2017:8

Waqas M, Jeong W-j, Lee Y-J, Kim DH, Ryou C, Lim Y-b (2017) pH-dependent in-cell self-assembly of peptide inhibitors increases the anti-prion activity while decreasing the cytotoxicity. Biomacromolecules 18(3):943-950

Waqas M, Lee HM, Kim J, Telling G, Kim JK, Kim DH, Ryou C. (2017) Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. Molecular and Cellular Biochemistry 428(1-2):5766

Omer Salman Qureshi, Hyung-Seo Kim, Alam Zeb, Jin-Seok Choi, Hoo-Seong Kim, Jung-Eun Kwon, Myung-Sic Kim, Jong-Ho Kang, Chongsuk Ryou, Jeong-sook Park & Jin-Ki Kim(2017)Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration. J Microencapsul 34(3):250-261

Okkeun Jung, Jongsung Lee, YuJin Lee, Jung-Mi Yun, Young-Jin Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee (2016) Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and β-catenin signaling pathways. Bioorg Med Chem Lett 26(16):3963-3967

Titlow WB, Waqas M, Lee J, Cho JY, Lee SY, Kim DH, Ryou C (2016) Effect of polylysine to scrapie prion protein propagation in spleen during asymptomatic stage of experimental prion disease in mice. Journal of Microbiology and Biotechnology 26(9): 1657-1660

Jeon J, Kim J, Park S, Ryou C, Kim C (2016) Preparative purification of plasmin activity stimulating phenolic derivatives from Gastrodia elata using centrifugal partition chromatography. Biomedical Chromatography 30(6):976-982.

Suh H, Choi K-w, Lee J, Ryou C, Rhee H, Lee C-H (2016) Effects of a novel carbocyclic analog of pyrrolo[2,3-d]pyrimidine nucleoside on pleiotropic induction of cell death in prostate cancer cells with different androgen responsiveness. Bioorganic & Medicinal Chemistry Letters 26(4):1130-1135

Choi K-w, Suh H, Oh HL, Ryou C, Lee C-H (2016) p21Cip1 induces apoptosis via binding to Bcl-2 in prostate cancer LNCaP cells treated with MCS-C3, a novel carbocyclic analog of pyrrolopyrimidine. Anticancer Research 36(1):213-220

Kim JH, Cho EB, Lee J, Jung O, Ryu BJ, Kim SH, Cho JY, Ryou C, Lee SY (2015) Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways. Chemico-Biological Interactions 242(2015):25-33

Hossen MJ, Kim SC, Son YJ, Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim HG, Chung WJ, Yoon K, Ryou C, Lee SY, Kim JH, Cho JY (2015) AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis. Evidence-Based Complementary and Alternative Medicine 2015:1-11

Lee J, Moh S-H, Ryou C, Kim D-H (2015) Enhanced formation of scrapie prion protein in cultured cells by treatment with mycosporine-like amino acids (MAAs). Korean Journal of Microbiology and Biotechnology 43(2):91-96

Lee J, Hyeon JW, Kim SY, Hwang K-J, Ju YR, Ryou C (2015) Laboratory diagnosis and surveillance of CreutzfeldtJakob disease. Journal of Medical Virology 87(1):175-86

Kim D-H, Lee H-M, Ryou C (2014) Evaluation of infective property of recombinant prion protein amyloids in cultured cells overexpressing cellular prion protein. Journal of Korean Medical Science 29(12):1604-1609

Lee H-M, Ryou C (2014) Targeting of poly(L-lysine) to organs that propagate prions. Journal of Bioactive and Compatible Polymers 29(5):432444

Yi Y-S, Son Y-J, Ryou C, Sung G-H, Kim J-H, Cho JY (2014) Functional roles of Syk in macrophage-mediated inflammatory responses. Mediators of Inflammation 2014:270302, 1-12

Kim S-G, Lee H-M, Ryou C (2014) Parameters that affect macromolecular self-assembly of prion protein. Protein Journal 33:243-252

Titlow WB, Lee C-H, Ryou C (2013) Characterization of toxicological properties of L-lysine polymers in CD-1 mice. Journal of Microbiology and Biotechnology 23(7): 1015-1022

Jackson KS, Yeom J, Han Y, Bae Y, Ryou C (2013) Preference toward a polylysine enantiomer in inhibiting prions. Amino Acids 44:993-1000

Mays CE, Yeom J, Kang H-E, Bian J, Khaychuk V, Kim Y, Bartz JC, Telling GC, Ryou C (2011) In vitro amplification of misfolded prion protein using lysate of cultured cells. PLoS ONE 6(3):e18047.

Ryou C, Titlow W, Mays CE, Bae Y, Kim S (2011) The suppression of prion propagation using poly-L-lysine by targeting plasminogen that stimulates prion protein conversion. Biomaterials 32(11):31413149

Lee H-J, Maeng K, Dang H-T, Kang G-J, Ryou C, Jung J, Kang H-K, Prchal J, Yoo E-S, Yoon D (2011) Anti-inflammatory effect of methyl dehydro-jasmonate is mediated by the NF-κB pathway. Journal of Molecular Medicine 89(1):83-90

Mays CE, Ryou C (2011) Plasminogen: a cellular protein cofactor for PrPSc propagation. Prion 5(1):22-27

Mays CE, Ryou C (2010) Plasminogen stimulates propagation of protease-resistant prion protein in vitro. FASEB Journal 24(12):5102-5112.

Lim Y-b, Mays CE, Kim Y, Titlow W, Ryou C (2010) The inhibition of prions through blocking prion conversion by permanently charged branched polyamines of low cytotoxicity. Biomaterials 31(8):2025-2033

Kim Y, Han B, Titlow W, Mays CE, Kwon M, Ryou C(2009) Utility of RNAi-mediated prnp gene silencing in neuroblastoma cells permanently infected by prions: Potentials and limitations. Antiviral Research 84(2):185-193

Mays CE, Titlow W, Seward T, Telling GC, Ryou C (2009) Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source. Biochemical Biophysical Research Communications 388(2): 306310.

Kim Y, Song J, Mays CE, Titlow W, Yoon D, Ryou C (2009) Changes in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prions. Molecular and Cellular Biochemistry 328(1-2):177-182

Ryou C, Mays CE (2008) Prion propagation in vitro: are we there yet? International Journal of Medical Sciences, 5(6):347-353.

Shin W, Lee B, Hong S, Ryou C, Kwon, M (2008) Cloning and expression of a prion protein (PrP) gene from Korean bovine (Bos taurus coreanae) and production of rabbit anti-bovine PrP antibody. Biotechnology Letters, 30:1705-1711.

Mays CE, Kang H-E, Kim Y, Shim SH, Bang J-E, Woo H-J, Cho Y-H, Kim J-B, Ryou C (2008) CRBL cells: Establishment, characterization and susceptibility to prion infection. Brain Research 1208:170-180.

Ryou C (2007) Prions and prion diseases: Fundamentals and mechanistic details. Journal of Microbiology and Biotechnology 17(7):1059-1070.

Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin MA, Prusiner SB, Ryou C, Guglielmo BJ (2004) Pharmacokinetics of quinacrine in the treatment of prion disease. BMC Infectious Diseases 4(1):53.

Ryou C, Legname G, Peretz D, Craig JC, Baldwin MA, Prusiner SB (2003) Differential inhibition of prion propagation by enantiomers of quinacrine. Laboratory Investigation, 83(6):837-843.

Ryou C, Prusiner SB, Legname G (2003) Cooperative binding of dominant negative prion proteins to kringle domains. Journal of Molecular Biology, 329(2):323-333.

Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond S, Prusiner SB (2002) Prions in skeletal muscle. Proceedings of National Academy of Science, U. S. A., 99(6):3812-3817.

Hadden TJ, Ryou C, Zhu L, Miller RE (2002) CAAT/Enhancer Binding Protein activates an enhancer in the glutamine synthetase distal 5'-flanking sequence. Archives of Biochemistry and Biophysics, 397(2): 258-261.

Lee J, Ryou C, Jeon BK, Lee P, Woo H-J, Kwon M (2002) Gene cloning and nucleotide sequence of human dihydrolipoamide dehydrogenase-binding protein. Asian-Australasian Journal of Animal Sciences, 15(3):421-426.

Ryou C, Chung T, Kwon M (2001) Molecular cloning and hyperexpression of a Bt gene, cryIAc, in Escherichia coli DH5a: production and usage of anti-cryIAc antibody. Journal of Microbiology and Biotechnology, 11(6):1093-1098.

Lee J, Ryou C, Kwon M (2001) Molecular cloning and expression of human dihydrolipoamide dehydrogenase-binding protein in Escherichia coli. Journal of Microbiology and Biotechnology, 11(4):592-597.

Kwon M, Lee JM, Jeon BK, Oh SG, Ryou C, Oh BH (2001) RFLP analysis of a gene for blood coagulation factor IX in Korean. Korean Journal of Obstetrics and Gynecology, 44(3):506-512.

Ryou C, Kim J-B, Kwon M (2000) Immunochemical studies on expression of quinoproteins in Escherichia coli. Journal of Microbiology and Biotechnology, 10(1):95-98.

Oh BH, Lee JM, Lee J, Lee KH, Jung AY, Ryou C, Kwon M. (2000) A case of pregnant woman with 46,X,del(X)(q26) Turner karyotype whose fetus shows the same karyotype. Korean Journal of Obstetrics and Gynecology, 43(4):721-724.

Lim JY, Shin CS, Chung E-J, Kim JS, Kim HU, Oh SJ, Choi W-B, Ryou C, Kim JB, Kwon M, Chung TY, Song SI, Kim J-K, Nahm BH, Hwang YS, Eun MY, Lee JS, Cheong J-J, Choi YD. (2000) Analysis of expressed sequence tagsfrom Brassica rapa L. ssp. pekinensis. Molecules and Cells, 10(4):399-404.

Cho KS, Jang JE, Ryou C, Kwon M. (1999) Development of Transgenic Plant (Codonopsis lanceolata Trautv.) harboring a bialaphos resistance gene, bar. Korean Journal of Plant Tissue Culture, 26(4): 281-287.

Hadden TJ, Ryou C, Miller RE. (1997) Elements in the distal 5-flanking sequence and the first intron function cooperatively to regulate glutamine synthetase gene expression during adipocyte differentiation. Nucleic Acids Research, 25(19):3930-3936.

Yu HJ, Kim J, Ryou C, Kwon M (1997) Generation of ETSs from dark-grown seedling cDNA of chinese cabbage. Korean Journal of Genetics, 19(3):205-213.

Jang S, Ryou C, Kim J, Lee P, Kwon M (1997) Construction of a mutant PU.1 cDNA clone, pJKS142A. Sungkyunkwan University Journal of Natural Sciences and Technology 3(2):107-115.

Lee JM, Ryou C, Kwon M (1997) Generation of transgenic plant (Nicotiana tabacum var. Petit Havana SR1) harboring Bacillus thuringiensis insecticidal crystal protein gene, cry II A. Korean Journal of Plant Tissue Culture, 24(5):305-311.

Ryou C, Yu S, Jang S, Kim M, Kim J, Kwon M. (1995) Molecular cloning of mutant cDNA of PU.1 gene. Korean Journal of Biotechnology and Bioengineering, 10(5): 499-509.

 

저서

 

Ryou C (2011) Prion diseases, In: Encyclopedia of Life Sciences, John Wiley & Sons Inc., Chichester, UK Ryou C, Mays CE (2010) Prions (Chapter 8), In: Molecular aspects of infectious diseases, Ed Saleh M, Nova Science Publisher, Hauppauge, New York. 

Ryou C (2010) Transmissible spongiform encephalopathy (Chapter 9), In: Molecular aspects of infectious diseases, Ed. Saleh M, Nova Science Publisher, Hauppauge, New York. 

Kwon M, Ryou C (2004) Genetic Engineering: Principles and Practices, Academy Book Publishing Co., Seoul, Korea

 

특허

류종석, 김철영, 이성은, 김지훈, 김재현(2022) 단백질응집에 의한 퇴행성 뇌질환 치료를 위한 아출 유래 약학 조성물, 출원번호 10-2022-0054006 (2022.05.02)

류종석, 김철영, 이성은(2022) 단백질응집 기반 프리온 질환치료를 위한 아출 유래 퓨라노다이에논을 포함하는 약학 조성물, 등록번호 10-2022-0051572 (2022.04.26) 

남태규, 이동윤, 김동환, 김예은, 류종석, 김재현, 유미령, 이학민, 이성은(2021) 세미카바자이드 유도체화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 프리온 질환의 예방 또는 치료용 약학적 조성물, 등록번호 10-2021-0151609 (2021.11.05) ​

류종석 손영진(2021) 고순도 재조합 프리온 단백질의 대량 생산 방법, 등록번호 10-2298635-0000 (2021.08.31)

류종석 트린티후엔트랑(2021) 아스피린을 유효성분으로 포함하는 프리온 질환의 예방 또는 치료용 조성물, 등록번호 1022108930000 (2021.01.27)

류종석 아툴 쿨카르니(2020) 실리콘 나노리본 전계효과트랜지스터를 이용한 프리온 검출 방법, 등록번호 1021249810000 (2020.06.15)

전용필 류종석(2020) 109번째 아미노산이 메티오닌인 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1021005100000 (2020.04.07)

전용필 류종석(2020) 109번째 아미노산이 아이소류신인 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1021005090000 (2020.04.07)

전용필 류종석(2020) 109번째 아미노산이 메티오닌이고 23번째에서 89번째 아미노산을 코딩하는 서열을 제거한 제방 들쥐의 프리온 단백질 유전자로 상동재조합된 녹인 생쥐 및 이의 응용, 등록번호 1020702570000 (2020.01.20)

임용범 류종석(2019) 세포 내부 pH 감응성 융합 펩티드 및 이를 유효성분으로 포함하는 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환을 예방 또는 치료하기 위한 약학 조성물, 등록번호 1019563020000 (2019.03.04)

류종석(2009) 프리온 질병 치료제, 등록번호 100881636 (2009.01.28)

류종석(2008) 변형 프리온 단백질에 의한 퇴행성 뇌질환의 치료제, 등록번호 100849422 (2008.07.24)  

 

Articles

JiaoJi Li, Chongsuk Ryou, Dae-Hwan Kim(2020) Effects of SGI-1027 on Formation and Elimination of PrPSc in Prion-Infected Cells. MOLECULAR CELL BIOLOGY 54(3):412-415 

Sungeun Lee, Hee-Gyoo Kang, Chongsuk Ryou, Yong-Pil Cheon (2020) Spatiotemporal expression of aquaporin 9 is critical for the antral growth of mouse ovarian follicles. Biology of Reproduction ioaa108

Trang H.T.Trinh, Jeeyoung Kim, Chul-Hoon Lee, Chongsuk Ryou (2019) Non-ionic detergents Nonidet P-40 and Triton X-100 increase enzymatic activity of plasmin. Biochemical and Biophysical Research Communications 512(2):314-318

Dae-Hwan Kim, Chunyan Ren, Chongsuk Ryou, Jiaojie Li (2019) Direct interaction of DNMT inhibitors to PrPC suppresses pathogenic process of prion. Acta Pharmaceutica Sinica B 9(5):952-959

Sungeun Lee, Trang H.T. Trinh, Miryeong Yoo, Junwu Shin, Hakmin Lee, Jaehyeon Kim, Euimin Hwang, Yong-beom Lim, Chongsuk Ryou (2019) Self-Assembling Peptides and Their Application in the Treatment of Diseases. International Journal of Molecular Sciences 20(23):5850

Juhye Kim, Sunyeong Cha, Min Young Lee, Yeon Jeong Hwang, Eunhyeok Yang, Chongsuk Ryou, Hyo-Il Jung and Yong-Pil Cheon (2018) Chronic Low-Dose Nonylphenol or Di-(2-ethylhexyl) Phthalate has a Different Estrogen-like Response in Mouse Uterus. Development & Reproduction 22(4):379-391

YuJin Lee, Okkeun Jung, Jongsung Lee, Juhyeon Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee (2018) Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling pathways. Nutrition Research 58:62-71

Hae-Eun Kang, Youngwon Mo, Raihah Abd Rahim, Hye-Mi Lee and Chongsuk Ryou(2017) Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion BioMed Research International 2017:8

Waqas M, Jeong W-j, Lee Y-J, Kim DH, Ryou C, Lim Y-b (2017) pH-dependent in-cell self-assembly of peptide inhibitors increases the anti-prion activity while decreasing the cytotoxicity. Biomacromolecules 18(3):943-950

Waqas M, Lee HM, Kim J, Telling G, Kim JK, Kim DH, Ryou C. (2017) Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. Molecular and Cellular Biochemistry 428(1-2):5766

Omer Salman Qureshi, Hyung-Seo Kim, Alam Zeb, Jin-Seok Choi, Hoo-Seong Kim, Jung-Eun Kwon, Myung-Sic Kim, Jong-Ho Kang, Chongsuk Ryou, Jeong-sook Park & Jin-Ki Kim(2017)Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration. J Microencapsul 34(3):250-261

Okkeun Jung, Jongsung Lee, YuJin Lee, Jung-Mi Yun, Young-Jin Son, JaeYoul Cho, Chongsuk Ryou, SangYeol Lee (2016) Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and β-catenin signaling pathways. Bioorg Med Chem Lett 26(16):3963-3967

Titlow WB, Waqas M, Lee J, Cho JY, Lee SY, Kim DH, Ryou C (2016) Effect of polylysine to scrapie prion protein propagation in spleen during asymptomatic stage of experimental prion disease in mice. Journal of Microbiology and Biotechnology 26(9): 1657-1660

Jeon J, Kim J, Park S, Ryou C, Kim C (2016) Preparative purification of plasmin activity stimulating phenolic derivatives from Gastrodia elata using centrifugal partition chromatography. Biomedical Chromatography 30(6):976-982.

Suh H, Choi K-w, Lee J, Ryou C, Rhee H, Lee C-H (2016) Effects of a novel carbocyclic analog of pyrrolo[2,3-d]pyrimidine nucleoside on pleiotropic induction of cell death in prostate cancer cells with different androgen responsiveness. Bioorganic & Medicinal Chemistry Letters 26(4):1130-1135

Choi K-w, Suh H, Oh HL, Ryou C, Lee C-H (2016) p21Cip1 induces apoptosis via binding to Bcl-2 in prostate cancer LNCaP cells treated with MCS-C3, a novel carbocyclic analog of pyrrolopyrimidine. Anticancer Research 36(1):213-220

Kim JH, Cho EB, Lee J, Jung O, Ryu BJ, Kim SH, Cho JY, Ryou C, Lee SY (2015) Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways. Chemico-Biological Interactions 242(2015):25-33

Hossen MJ, Kim SC, Son YJ, Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim HG, Chung WJ, Yoon K, Ryou C, Lee SY, Kim JH, Cho JY (2015) AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis. Evidence-Based Complementary and Alternative Medicine 2015:1-11

Lee J, Moh S-H, Ryou C, Kim D-H (2015) Enhanced formation of scrapie prion protein in cultured cells by treatment with mycosporine-like amino acids (MAAs). Korean Journal of Microbiology and Biotechnology 43(2):91-96

Lee J, Hyeon JW, Kim SY, Hwang K-J, Ju YR, Ryou C (2015) Laboratory diagnosis and surveillance of CreutzfeldtJakob disease. Journal of Medical Virology 87(1):175-86

Kim D-H, Lee H-M, Ryou C (2014) Evaluation of infective property of recombinant prion protein amyloids in cultured cells overexpressing cellular prion protein. Journal of Korean Medical Science 29(12):1604-1609

Lee H-M, Ryou C (2014) Targeting of poly(L-lysine) to organs that propagate prions. Journal of Bioactive and Compatible Polymers 29(5):432444

Yi Y-S, Son Y-J, Ryou C, Sung G-H, Kim J-H, Cho JY (2014) Functional roles of Syk in macrophage-mediated inflammatory responses. Mediators of Inflammation 2014:270302, 1-12

Kim S-G, Lee H-M, Ryou C (2014) Parameters that affect macromolecular self-assembly of prion protein. Protein Journal 33:243-252

Titlow WB, Lee C-H, Ryou C (2013) Characterization of toxicological properties of L-lysine polymers in CD-1 mice. Journal of Microbiology and Biotechnology 23(7): 1015-1022

Jackson KS, Yeom J, Han Y, Bae Y, Ryou C (2013) Preference toward a polylysine enantiomer in inhibiting prions. Amino Acids 44:993-1000

Mays CE, Yeom J, Kang H-E, Bian J, Khaychuk V, Kim Y, Bartz JC, Telling GC, Ryou C (2011) In vitro amplification of misfolded prion protein using lysate of cultured cells. PLoS ONE 6(3):e18047.

Ryou C, Titlow W, Mays CE, Bae Y, Kim S (2011) The suppression of prion propagation using poly-L-lysine by targeting plasminogen that stimulates prion protein conversion. Biomaterials 32(11):31413149

Lee H-J, Maeng K, Dang H-T, Kang G-J, Ryou C, Jung J, Kang H-K, Prchal J, Yoo E-S, Yoon D (2011) Anti-inflammatory effect of methyl dehydro-jasmonate is mediated by the NF-κB pathway. Journal of Molecular Medicine 89(1):83-90

Mays CE, Ryou C (2011) Plasminogen: a cellular protein cofactor for PrPSc propagation. Prion 5(1):22-27

Mays CE, Ryou C (2010) Plasminogen stimulates propagation of protease-resistant prion protein in vitro. FASEB Journal 24(12):5102-5112.

Lim Y-b, Mays CE, Kim Y, Titlow W, Ryou C (2010) The inhibition of prions through blocking prion conversion by permanently charged branched polyamines of low cytotoxicity. Biomaterials 31(8):2025-2033

Kim Y, Han B, Titlow W, Mays CE, Kwon M, Ryou C(2009) Utility of RNAi-mediated prnp gene silencing in neuroblastoma cells permanently infected by prions: Potentials and limitations. Antiviral Research 84(2):185-193

Mays CE, Titlow W, Seward T, Telling GC, Ryou C (2009) Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source. Biochemical Biophysical Research Communications 388(2): 306310.

Kim Y, Song J, Mays CE, Titlow W, Yoon D, Ryou C (2009) Changes in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prions. Molecular and Cellular Biochemistry 328(1-2):177-182

Ryou C, Mays CE (2008) Prion propagation in vitro: are we there yet? International Journal of Medical Sciences, 5(6):347-353.

Shin W, Lee B, Hong S, Ryou C, Kwon, M (2008) Cloning and expression of a prion protein (PrP) gene from Korean bovine (Bos taurus coreanae) and production of rabbit anti-bovine PrP antibody. Biotechnology Letters, 30:1705-1711.

Mays CE, Kang H-E, Kim Y, Shim SH, Bang J-E, Woo H-J, Cho Y-H, Kim J-B, Ryou C (2008) CRBL cells: Establishment, characterization and susceptibility to prion infection. Brain Research 1208:170-180.

Ryou C (2007) Prions and prion diseases: Fundamentals and mechanistic details. Journal of Microbiology and Biotechnology 17(7):1059-1070.

Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin MA, Prusiner SB, Ryou C, Guglielmo BJ (2004) Pharmacokinetics of quinacrine in the treatment of prion disease. BMC Infectious Diseases 4(1):53.

Ryou C, Legname G, Peretz D, Craig JC, Baldwin MA, Prusiner SB (2003) Differential inhibition of prion propagation by enantiomers of quinacrine. Laboratory Investigation, 83(6):837-843.

Ryou C, Prusiner SB, Legname G (2003) Cooperative binding of dominant negative prion proteins to kringle domains. Journal of Molecular Biology, 329(2):323-333.

Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond S, Prusiner SB (2002) Prions in skeletal muscle. Proceedings of National Academy of Science, U. S. A., 99(6):3812-3817.

Hadden TJ, Ryou C, Zhu L, Miller RE (2002) CAAT/Enhancer Binding Protein activates an enhancer in the glutamine synthetase distal 5'-flanking sequence. Archives of Biochemistry and Biophysics, 397(2): 258-261.

Lee J, Ryou C, Jeon BK, Lee P, Woo H-J, Kwon M (2002) Gene cloning and nucleotide sequence of human dihydrolipoamide dehydrogenase-binding protein. Asian-Australasian Journal of Animal Sciences, 15(3):421-426.

Ryou C, Chung T, Kwon M (2001) Molecular cloning and hyperexpression of a Bt gene, cryIAc, in Escherichia coli DH5a: production and usage of anti-cryIAc antibody. Journal of Microbiology and Biotechnology, 11(6):1093-1098.

Lee J, Ryou C, Kwon M (2001) Molecular cloning and expression of human dihydrolipoamide dehydrogenase-binding protein in Escherichia coli. Journal of Microbiology and Biotechnology, 11(4):592-597.

Kwon M, Lee JM, Jeon BK, Oh SG, Ryou C, Oh BH (2001) RFLP analysis of a gene for blood coagulation factor IX in Korean. Korean Journal of Obstetrics and Gynecology, 44(3):506-512.

Ryou C, Kim J-B, Kwon M (2000) Immunochemical studies on expression of quinoproteins in Escherichia coli. Journal of Microbiology and Biotechnology, 10(1):95-98.

Oh BH, Lee JM, Lee J, Lee KH, Jung AY, Ryou C, Kwon M. (2000) A case of pregnant woman with 46,X,del(X)(q26) Turner karyotype whose fetus shows the same karyotype. Korean Journal of Obstetrics and Gynecology, 43(4):721-724.

Lim JY, Shin CS, Chung E-J, Kim JS, Kim HU, Oh SJ, Choi W-B, Ryou C, Kim JB, Kwon M, Chung TY, Song SI, Kim J-K, Nahm BH, Hwang YS, Eun MY, Lee JS, Cheong J-J, Choi YD. (2000) Analysis of expressed sequence tagsfrom Brassica rapa L. ssp. pekinensis. Molecules and Cells, 10(4):399-404.

Cho KS, Jang JE, Ryou C, Kwon M. (1999) Development of Transgenic Plant (Codonopsis lanceolata Trautv.) harboring a bialaphos resistance gene, bar. Korean Journal of Plant Tissue Culture, 26(4): 281-287.

Hadden TJ, Ryou C, Miller RE. (1997) Elements in the distal 5-flanking sequence and the first intron function cooperatively to regulate glutamine synthetase gene expression during adipocyte differentiation. Nucleic Acids Research, 25(19):3930-3936.

Yu HJ, Kim J, Ryou C, Kwon M (1997) Generation of ETSs from dark-grown seedling cDNA of chinese cabbage. Korean Journal of Genetics, 19(3):205-213.

Jang S, Ryou C, Kim J, Lee P, Kwon M (1997) Construction of a mutant PU.1 cDNA clone, pJKS142A. Sungkyunkwan University Journal of Natural Sciences and Technology 3(2):107-115.

Lee JM, Ryou C, Kwon M (1997) Generation of transgenic plant (Nicotiana tabacum var. Petit Havana SR1) harboring Bacillus thuringiensis insecticidal crystal protein gene, cry II A. Korean Journal of Plant Tissue Culture, 24(5):305-311.

Ryou C, Yu S, Jang S, Kim M, Kim J, Kwon M. (1995) Molecular cloning of mutant cDNA of PU.1 gene. Korean Journal of Biotechnology and Bioengineering, 10(5): 499-509.

 

Book and Book Chapters

 

Ryou C (2011) Prion diseases, In: Encyclopedia of Life Sciences, John Wiley & Sons Inc., Chichester, UK Ryou C, Mays CE (2010) Prions (Chapter 8), In: Molecular aspects of infectious diseases, Ed Saleh M, Nova Science Publisher, Hauppauge, New York. 

Ryou C (2010) Transmissible spongiform encephalopathy (Chapter 9), In: Molecular aspects of infectious diseases, Ed. Saleh M, Nova Science Publisher, Hauppauge, New York. 

Kwon M, Ryou C (2004) Genetic Engineering: Principles and Practices, Academy Book Publishing Co., Seoul, Korea

 

Patents

Ryou C, Trang H.T.Trinh(2021) The Composition Comprised of Aspirin for Preventing or Treating Prion Diseases, Korean Patent Registration #1022108930000

Ryou C(2021) Method for detecting prions using silicon nanoribbon field effect transistor,Korean Patent Registration, #1021249810000 

Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS METHIONINE AND APPLICATIONS THEREOF, Korean Patent Registration #1021005100000 

Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS ISOLEUCINE AND APPLICATIONS THEREOF, Korean Patent Registration #1021005090000 

Yong-pil Cheon, Ryou C(2020) KNOCK-IN MOUSE HOMOLOGOUS RECOMBINATED BY BANK VOLE'S PRION PROTEIN GENE WHICH 109TH AMINO ACID IS METHIONINE AND FROM 23TH TO 89TH AMINO ACID CODING SEQUENCES ARE ELIMINATED, AND APPLICATIONS THEREOF, Korean Patent Registration #1020702570000 

Yong-beom Lim, Ryou C(2019) intracellular pH-responsive fusion peptide, phamaceutical composition for treatment of protein aggregation and misfolding related diseases, Korean Patent Registration #1019563020000


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